Announcement of Opportunity (AO) For Human Analogue Studies
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Publication date:
Applications due .
Summary of Key Information
- Eligible Recipients:
- Canadian post-secondary institutions, defined as a Canadian university or college (including CEGEPs in Quebec) that has provincial accreditation to grant degrees, diplomas, certificates or other recognized qualifications;
- Not for profit organizations established and operating in Canada that have research included in their institutional mandate, and that have a standing Research Ethics Board (as defined by the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans), or that delegate this responsibility to another institution's recognized board.
- Funding Type Grants
- Maximum amount per project: up to $300,000
- Maximum duration of the project: up to three (3) years, beginning no earlier than .
1 INTRODUCTION
In the future, human exploration of space is expected to extend beyond Low Earth Orbit (LEO) to cis-lunar space, the surface of the Moon, and ultimately to distant targets such as Mars. The resulting expeditions will require extended periods of exposure to weightlessness and space radiation, with confinement and isolation in the extreme environment of space, all of which are linked to substantial human health and performance risks.
The Canadian Space Agency (CSA) supports human spaceflight and maintaining a healthy and highly qualified Canadian astronaut corps capable of participating in space exploration missions. Also, as stated in the vision and priorities of the recent Space Strategy for Canada, the CSA aims to enable scientific opportunities and global partnerships, and to harness space to solve everyday challenges for Canadians.
To achieve this, the CSA's Health and Life Sciences (HLS) group conducts activities generating knowledge in fields that sustain human space flights, mitigate health risks and develop countermeasures for these missions. Since time and resources on International Space Station (ISS) are limited, CSA aims to broaden science opportunities in order to enhance and supplement flight investigations on the ISS and to optimize utilization of CSA's ISS allocation.
The intent of this Announcement of Opportunity (AO) is to provide financial support to researchers in Canadian Universities, post-secondary institutions, and not for profit organizations to conduct science investigations that will lead to a better understanding of human spaceflight risks while contributing to improve remote medicine and health benefits here on Earth. The focus of research to be funded in this AO will be on human-subject space analogue studies that reproduce the health and performance factors of space environments such as variable gravity, isolation, and confinement. Well-designed ground studies are valuable for improving the understanding of the risks of spaceflight or for initial validation of new countermeasures. The studies targeted in this AO must be precursors of Canadian investigations on the ISS or lunar Gateway.
Throughout the domestic and international space research community, there is a range of research institutes and installations that can support analogue platforms. If Canadian principal investigators (PIs) (or co-principal investigator (Co-PI)) or Co-Investigators (Co-Is) are selected by the soliciting agency for implementation of the proposal, they can then submit an application for funding to this CSA Announcement of Opportunity. Examples of competitions to be funded through this AO are listed in Table 1 of section 3.1 (other competitions not listed in Table 1 may also be eligible, provided that the principal aim of the analogue study is to better understand the health risks linked to human spaceflight, or to assess the efficacy of novel countermeasures against these risks, and that the partner agency has conducted a peer review of proposals prior to selection).
This AO is consistent with the terms and conditions of the CSA Class Grant and Contribution (G&C) Program to Support Research, Awareness and Learning in Space Science and Technology – Research Component.
Applicants are asked to read the following AO thoroughly before submitting their applications. This AO was prepared to help applicants complete the application process and outlines key elements, including mandatory criteria for eligibility, details on eligible projects and the selection process. In the event of any discrepancies between this AO and the individual funding agreements governing a project, the latter document(s) will take precedence.
2 AO OBJECTIVES
Projects selected from this CSA competition must have as their objective to increase scientific knowledge that will contribute to the efforts toward the understanding, mitigation or elimination of health risks associated with human space exploration, and to generate scientific insights that will contribute to applications on Earth.
More specifically, through this AO, the CSA seeks to:
- Create an opportunity for new space life science experiments to generate knowledge and insight into the risks of human space flight, with the ultimate objective to keep astronauts healthy in space. All proposed studies must clearly indicate how they are a direct precursor of future Canadian investigations on the ISS or Lunar Gateway;
- Advance understanding of similar health issues or applications on Earth, that could contribute to improving health of Canadians;
- Foster the development of highly qualified personnel (HQP), and inclusion of diversity of HQP in space health and life sciences.
3 ELIGIBILITY CRITERIA
In this section 3
3.1 Eligible Recipients
Eligible recipients (beneficiaries) for grants are:
- Canadian post-secondary institutions, defined as a Canadian university or college (including CEGEPs in Quebec) that has provincial accreditation to grant degrees, diplomas, certificates or other recognized qualifications;
- Not for profit organizations established and operating in Canada that have research included in their institutional mandate, and that have a standing Research Ethics Board (as defined by the Tri-Council Policy Statement: Ethical Conduct for Research Involving Humans), or that delegate this responsibility to another institution's recognized board.
3.2 Eligible Projects
Projects eligible for funding in this solicitation process are those where Canadian researchers are involved as PI (or Co-PI) or as Co-I of a proposal that has been selected based on scientific merit through one of the international partner competitions. The principal investigator must hold a traditionally recognized academic position such as professor, associate professor, assistant professor, or professor emeritus (post-doctoral fellows cannot be considered as PI). Individuals who are paid salary through someone else's research grant are not eligible as a PI. Examples of accepted competitions can be found in Table 1.
| Competitions | Proposal due date | Canadian participant status |
|---|---|---|
| Ground-Based Facilities (ESA) | Open | PI (or co-PI) or Co-I |
| Parabolic flights (ESA) | Open | PI (or co-PI) or Co-I |
| DLR Parabolic flights | Open | Co-I (in collaboration with a German PI) |
3.3 Links to CSA Priorities
To be eligible, projects supported under the G&C program must be aligned with CSA priority outcomes, as stated in the - Departmental Plan: Leveraging deep-space health and food innovations. In accordance to its mandate, the activities selected must 1) generate new knowledge and insight into the risks of human space flight to keep astronauts healthy in space (Space Strategy for Canada, ), and 2) they must clearly be recognizable as direct precursors of future Canadian investigations on the ISS or Lunar Gateway, and 3) they must generate strategies for novel countermeasures against the risks of human space flight. The most important health risks associated with human space flights (i.e. future long-duration human spaceflight missions) have been listed in Table 2.
In addition to the risks listed in the table below, the CSA will also evaluate if the activities would contribute to advance understanding of similar health issues or translate to applications on Earth, or that could contribute to improving health care for Canadians.
The following table presents the human space flight risks targeted by the CSA for this application process.
| Object | Action |
|---|---|
| Musculoskeletal | Mission risks resulting from reduced muscle strength and aerobic capacity, and increased bone fragility |
| Sensorimotor | Mission risks resulting from sensory changes/dysfunctions |
| Metabolism | Mission risks associated with metabolism and the effects of nutrient composition of diet on health during space missions |
| Behavioural Health and Performance | Mission behavioural health and performance risks, for example, associated with psychological adaptation, stress and fatigue, cognitive deterioration or issues with team dynamics |
| Radiation | Mission risk due to health and performance impairment associated with radiation damage |
| Variable Gravity and Planetary-Lunar Missions | Mission risks associated with physiological adaptation (including Space Associated Neuro-optical Syndrome) during transit (i.e. long duration exposure to microgravity) and sojourn on planetary surfaces. Note that physiological adaptation includes adaptation of human-associated microbial communities. Other risks can be associated with planetary exploration and can include, for instance, exposure to dust. |
3.4 Links to the Class G&C Program Objectives
To be eligible, projects supported under the G&C program must contribute to the achievement of at least one of the following objectives:
- To support the development of science relevant to the priorities of the Canadian Space Agency;
- To foster the continuing development of a critical mass of researchers and highly qualified people in Canada in areas relevant to the priorities of the Canadian Space Agency.
4 APPLICATION
In this section 4
4.1 Required Documentation
The required documentation can be uploaded electronically.
The application must include the following:
- The full proposal, with a completed original application form signed by the duly authorized representative. For electronic submission, digital signature is required.
- A copy of the document(s) confirming the legal name of the applicant (must be confirmed by the organization's Office of Research);
- For Not-for-profit organizations, an original or certified copy of their certificate of constitution, letters patent, or other constitutive documents. Non-original or uncertified copies are accepted for the purposes of the application, but subsequently the original documents will be required at the time of the signing of the agreement;
- Letters from other funding contributors confirming the level of funding, if applicable;
- For Canadian Co-Is associated with an international study, a letter from the PI is required, confirming that the proposed work by the Co-I will enhance the study;
- Letter of support from Co-Is confirming their intent to participate to the study, including information on the potential source of funds, if applicable;
- Letter of acknowledgement received from the partner agency showing that the project has been selected through one of the competitions. Applicants are also required to provide CSA with the results of the Science Merit Review when they are received. CSA will use this result as science merit score. Applicants must obtain a passing score from the international partner competition to be considered by CSA;
- Letter of acknowledgement received from a partner agency showing that the project has been selected through one of its competitions. Applicants are also required to provide to CSA the Science Merit assessments when they are received. CSA will use this result as the science merit score. Applicants' proposals must obtain a passing score from the international Partner competition to be considered by CSA;
- Copy of the complete application submitted to the International Partner, including a complete financial package justifying the total cost of the study, if applicable;
- The applicant will ensure that ethical certification requirements are met throughout the study. A letter signed by the chairperson of the local Research Ethics Board (REB) regarding approval of the experimental protocol using human subjects will be required to that effect. REB approval letters for any subsequent protocol amendments must also be forwarded to the CSA;
- A Data Management Plan shall be provided with the proposal and it shall address:
- Types of data products;
- Short-term data preservation approach;
- Long-term data preservation/archiving approach;
- Formats for data and metadata;
- Roles and Responsibilities for data management within the team;
- Declaration on Confidentiality, Access to Information Act and Privacy Act form signed by the duly authorized representative (refer to the Applicant Declaration on Confidentiality, Access to Information Act and Privacy Act section included in the application form); and
- For organizations in Quebec, M-30 Supporting Documentation form completed and signed by the duly authorized representative (refer to the M-30 form for organizations in Quebec included in the application form).
It is the applicant's responsibility to ensure that the application complies with all relevant federal, provincial and territorial legislation and municipal bylaws (federal, provincial/territorial and municipal).
The application, uploaded electronically, must be submitted as a single PDF-formatted file containing all of the above requested documents with all security features disabled. Please order the document with the application form and proposal first. The proposal and supporting documents must be submitted as a searchable PDF-formatted documents (PDF/A-1a or PDF/A-2a formats preferred). If there are any accessibility issues with the submitted PDF file, all consequences reside with the applicant.
The applicant must keep one hard copy of all the original documents above. The CSA may require applicants who successfully passed the evaluation stage described in Section 5 of the AO to send a hard copy of their complete application with the original documents.
Process for electronic submission:
- The applicant must complete an account creation request at the Electronic Proposal Portal. Upon receipt, the CSA will send an email with instructions on how to connect to the CSA secure filer system to allow you to upload documents securely. Please note that Chrome is the browser of choice for submissions. Supported browsers are Google Chrome and, Internet Explorer with some restrictions.
- Allow up to seventy two (72) hours for the CSA to send an email confirming the account creation as well as instructions (user guide) on how to access the platform. It is strongly recommended that the account creation request be submitted no later than . If technical issues cannot be resolved, applicants must submit their application by mail. Applicants are strongly encouraged to upload their complete application well before the submission deadline;
- Using the temporary password assigned by the CSA, login to the secured portal to upload protected documents.
- Please refer to the user guide for instructions on how to securely upload documents.
- Applications must be submitted (successfully uploaded) by applicants no later than 2:00 PM (EDT), .
- Incomplete or late applications shall not be considered. A late application is considered to be one that has an electronic timestamp on the CSA system later than the deadline above.
Process for application sent by mail:
The applicant is encouraged to submit their application electronically following the instructions provided in Section 4.1 of the AO. However, if the applicant is unable to submit their application electronically, please communicate with santespatiale-spacehealth@asc-csa.gc.ca no later than at 2:00 PM (ET), to obtain instructions on how to submit a paper application by mail.
- For application sent by mail, one original paper copy of the full proposal, with a completed original application form signed by the duly authorized representative is required. In addition, a copy of the application (identical to the signed paper copy) in a PDF file (on a USB flash drive) is required. If there is any discrepancy between the hard and the soft version, the hard copy takes precedence;
Applications by mail must be received at the CSA no later than at 2:00 PM (ET). Applications sent by email will not be accepted. Incomplete applications may not be considered. The CSA is not responsible for any delays under any circumstances, and will refuse applications that are received after the stipulated deadline.
Questions and answers related to this AO will be posted on the CSA website in the Frequently Asked Questions (Section 9).
4.2 Service Standards – Complete Applications
CSA has set service standards for the timely delivery of the acknowledgement of receipt, funding decision and payment processes.
Acknowledgement: CSA goal is to acknowledge receipt within two (2) weeks of receiving a completed application package.
Decision: The CSA's goal is to respond to the application within forty-six (46) weeks following the AO's closing date and to send a grant agreement for signature within eight (8) weeks after formal approval of the application.
Payment: CSA goal is to issue payments within four (4) weeks of the successful fulfillment of requirements outlined in the grant agreement.
Compliance with these service standards is a shared responsibility. The applicant must submit all required documentation in a timely fashion.
5 EVALUATION
In this section 5
5.1 Eligibility Criteria
- Represents an eligible recipient as defined in Section 3.1;
- Represents an eligible project as defined in Sections 3.2, 3.3, and 3.4;
- Meets program funding provisions in Section 6.1.
An evaluation committee will screen applications according to the eligibility criteria described in Table 8 in ANNEX 1.
5.2 Evaluation Criteria
Submissions will be evaluated using the following graded criteria. These criteria and ratings are listed in Table 3. A detailed description of these graded criteria can be found in ANNEX 2. The eligible projects to be evaluated in this selection process will have already been evaluated for scientific merit through the international partner competition processes; therefore the CSA will focus its evaluation on the criteria listed in Table 3. To be considered eligible for funding, the total score obtained for these graded criteria must be greater than 120/200.
| Criteria | Maximum score | Passing score |
|---|---|---|
| 1. Benefits to Canada | ||
| 1.1 Alignment with the priorities of the CSA and Health & Life Sciences Program | 20 | 10 |
| 1.2 Link to future space studies | 15 | 7 |
| 1.3 Benefits on Earth | 20 | 10 |
| 1.4 Equity, diversity and inclusion (EDI) | 5 | 2 |
| 2. Project Feasibility, Resources allocation, and Risk assessment | ||
| 2.1 Budget, Resources Allocation and Schedule | 20 | 10 |
| 2.2 Risk management and Mitigation strategies | 20 | 10 |
| 3. Results | ||
| 3.1 Results of the Scientific Merit Review (External peer review led by partners) | 100 | Minimum score required is a passing score on the International Partner Scientific Merit Review. |
| Total | 200 | 120Footnote 1 |
5.3 Evaluation Process
Only applications that have passed the eligibility assessment listed in Section 5.1 will be given further consideration.
Once the eligibility criteria are confirmed, evaluators will assess the screened applications according to the criteria listed in Section 5.2. Evaluators shall be experts in the fields relevant to the applications and may include representatives of Canada and other countries, and representatives of other government and non-government agencies and organizations. If applicable, a multidisciplinary evaluation committee will be formed when applications from several different disciplines are competing in order to provide a uniform final score and ranking of proposals.
Before a final decision is made, the CSA's Program Manager responsible may seek input and advice from other organizations, including (but not limited to) federal, provincial, territorial and municipal government agencies and organizations. Grant agreements will be offered to the applicants in the rank order of the proposals while allowing considerations to maximize the use of available funding.
The results obtained in this selection process could take into account certain factors in the final decision to grant funding, such as, but not limited to, the representativeness of PI (or co-PI) or Co-I to one of the four (4) designated groups (women, Aboriginal persons, disabled persons or members of a visible minority), regional distribution, diversity among universities/organizations and post-secondary institutions, etc.
6 FUNDING
In this section 6
6.1 Available Funding and Duration
The total maximum funding amount given in grant for each project and the maximum duration depends on the initiative being targeted by the proposal. In all cases, the maximum funding includes overhead costs.
Maximum amount per grant:
- Proposals from PI (or Co-PI), maximum grant of $300,000 for a maximum duration of three (3) years;
- Proposals from Co-I, maximum grant of $150,000 for a maximum duration of three (3) years;
For each submitted proposals, justification for the requested funds needs to be complete and detailed. CSA reserves the right to adjust the maximum amount requested if CSA considers the justifications not sufficient or adequate.
The overall number of grants awarded and their level will depend on budget requested by each proposal and the availability of funds. CSA may prioritize PI proposals over Co-I proposals for funding.
There is no limit on the number of proposals presented per investigator. However, because of the limited funding available, the CSA will only fund one (1) project for a researcher as a PI (or Co-PI) in this application process.
In the event a Canadian-led proposal has one (1) or more Canadian Co-Is, only the PI can apply for funding. If a European-led proposal has more than one (1) Canadian Co-I, the Canadian Co-Is can only submit one (1) application for funding to the CSA. The CSA reserves the right to reject any proposals or reduce the amount of the grants at its entire discretion.
Approved proposals will be eligible for a total amount of government assistance (federal, provincial, territorial and municipal) of up to 100% of total project costs.
To determine the amount of funding to be allocated, consideration will be given to the availability of CSA funds, the total cost of the project, and the other confirmed sources of funds provided by other stakeholders and the applicant. CSA reserves the right to readjust the maximum amount requested if CSA considers the justifications not sufficient or adequate.
Applicants must identify all sources of funding in their applications and confirm this information in a funding agreement if the project is selected for funding. Upon completion of a project, the recipient must also disclose all sources of funding.
6.2 Eligible Costs
Eligible costs are direct expenses that are associated with the delivery of the approved project and that are required to achieve the expected results of the project. Expenses will be covered, subject to the applicant signing a funding agreement with the CSA.
Applicants to this CSA process cannot include as eligible costs any costs related to non-Canadian Co-Is or non-Canadian PIs or their work within the proposal. These costs should be submitted to the appropriate national agency for funding.
Eligible costs for grants in this application process are the following:
- Accommodation and meal allowances;
- Acquisition, development and printing of materials;
- Acquisition or rental of equipment;
- Bursaries, such as stipends for students involved in the project;
- Consultant services;
- Costs related to obtaining security clearance;
- Data acquisition;
- Data management;
- Laboratory analysis services;
- License and permit fees;
- Marketing and printing services;
- Materials and supplies;
- Overhead (administrative) costs (not to exceed 20% of eligible costs for universities and 15% for other eligible recipients);
- Participation fees at conferences, committees and events;
- PST, HST and GST net of any rebate to which the recipient is entitled and the reimbursement of any taxes for goods and services acquired in a foreign country net of any rebate or reimbursement received in the foreign country;
- Publication and communication services;
- Registration fees;
- Salaries and benefits;
- Training;
- Translation services;
- Travel.
7 FUNDING AGREEMENTS
In this section 7
7.1 Payments
The CSA and each successful applicant (the recipient) will sign a funding agreement. This is a condition for any payment made by the CSA with respect to the approved project.
For grant agreements, payments will be made in a lump sum or instalments as described in the signed agreement. Grant funding agreements will include a clause stipulating the recipient's obligation to confirm—once a year in the case of multi-year agreements—their eligibility for the G&C Program – Research Component and inform the CSA in writing of any changes to the conditions used in determining their eligibility for this component.
7.2 Audit
The recipient of a funding agreement shall keep proper records of all documentation related to the funded project, for the duration of the project and for six (6) years after the completion date of the project, in the event of an audit. This documentation shall be available upon request.
7.3 Conflict of Interest
In the funding agreement, the recipient will certify that any current or former public office holder or public servant it employs complies with the provisions of the relevant Conflict of Interest and Post-Employment Code for Public Office Holders and the Values and Ethics Code for the Public Sector respectively.
7.4 Intellectual Property
All intellectual property developed by the recipient in the course of the project shall vest in the recipient.
7.5 Organizations in Quebec
An organization in Quebec whose operations are partially or fully funded by the province of Quebec may be subject to the Act respecting the Ministère du Conseil exécutif, CQLR c M-30.
Under Sections 3.11 and 3.12 of this Act, certain entities/organizations, as defined in the meaning of the Act, such as municipal bodies, school bodies, or public agencies, must obtain authorization from the Secrétariat du Québec aux relations canadiennes (SQRC), as indicated by the Act, before signing any funding agreement with the Government of Canada, its departments or agencies, or a federal public agency.
Consequently, an entity that is subject to the Act is responsible for obtaining such authorization before signing any funding agreement with the Government of Canada.
Quebec applicants must complete, sign and include the M-30 Supporting Documentation form with their application.
7.6 Performance Measurement
The CSA will ask recipients to report on certain aspects of their projects such as:
- Knowledge Creation
- Knowledge production (including publications)
- Presentations
- Intellectual property (including patents)
- Capacity Building
- Project's research team (including highly qualified personnel supported)
- Collaboration
- Partners' contributions
- Partnerships
- Multidisciplinarity
7.7 Open Access Publications
In the event that publications result from the project, the CSA wishes to promote the dissemination of findings that results from the projects it funds as quickly and to the greatest number of people as possible. Improved access to scientific results not only allows scientists to use a broader range of resources and knowledge, but also improves research collaboration and coordination, strengthens citizen engagement and supports the economy.
The CSA therefore strongly encourages the use of open access publication and archiving by recipients in order to facilitate the widest dissemination of findings that results from its funded projects. Thus, recipients are invited to publish, in a timely manner, their articles by using at least one (1) of the following methods:
- Accessible online repository (institutional or disciplinary) so that the publication is freely accessible.
- Journal offering open access to articles.
It should be noted that these two (2) methods are not mutually exclusive and that recipients are encouraged to use both.
Finally, the CSA wishes to receive, as a courtesy, a copy of the publications (if not freely accessible) or the hyperlink (if freely accessible) and its digital object identifier (DOI). These will be use to improve accessibility by including them in the CSA publications directory.
8 PRIVACY NOTICE STATEMENT
The CSA manages and protects the information provided by the applicant under the Privacy Act and the Access to Information Act. By submitting your personal information, you consent to its collection, use and disclosure in accordance with the following Privacy Statement, which explains how the information about the applicant will be processed.
The information is collected under the CSA Class Grants and Contributions Program in Support of Awareness, Research and Learning - Research Component (ASC PPU 045) and Awareness and Learning Component (ASC PPU 040). This information will be used for administration and application evaluation purposes. Personal information (such as name, contact information and biographical information) will be kept for six (6) years and destroyed. According to the Privacy Act, any individual may, upon request, 1. have access to his or her personal data and 2. request correction of the incorrect information.
Applicants should also note that information relating to the Funding Agreement could be disclosed publicly in accordance with the laws, policies and directives of the Government of Canada.
For additional information regarding this statement, please contact:
Office of Access to Information and Privacy
Canadian Space Agency
Tel: 450-926-4866
E-mail: asc.aiprp-atip.csa@canada.ca
9 FREQUENTLY ASKED QUESTIONS (FAQ)
It is the responsibility of the applicants to obtain clarification of the requirements contained herein, if necessary, before submitting an application.
For any questions related to the AO, applicants shall use the following generic email address (santespatiale-spacehealth@asc-csa.gc.ca). Questions and answers related to this AO will be posted on the CSA website in the Frequently Asked Questions section of this AO. The CSA will respond to questions received before 2:00 PM (EDT), .
At any point, applicants are welcome to share with the CSA their comments or suggestions regarding the program or the process. Applicants may either use the generic email address (asc.lecedessetc-thegandccoe.csa@canada.ca) or the generic web-based Comments and Suggestions Box.
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Question 1: Will it be possible to obtain an extension to the current deadline of order to complete the proposal and/or obtain the necessary approvals?
Answer 1: The evaluation process will begin right after the AO closes, and extending the AO posting puts the evaluation schedule at risk and delays funding of successful proposals. Therefore, a change of deadline is unfortunately not possible.
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Question 2: In the Application form regarding your recent Announcement of Opportunity (AO), it is indicated that the full proposal description should be around 2500 words in MS Word format(.DOC, .DOCX), 12-pt typeface, letter-sized paper and 1" margins. Could you please clarify the followings: Are there specific requirements for line spacing? Is it possible to include figures and tables presenting preliminary data in the proposal? Are references included in the maximum limit of 2500 words?
Answer 2: Here are some details about the description of the research proposal:
- Proposals are usually written in single space format; however, there is no preference/requirement for line spacing.
- Figures and tables presenting preliminary data can be included, but all legends and text will count towards the maximum limit of 2500 words.
- References are not included in the maximum limit of 2500 words.
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Question 3: In the AO, under 4.1 Required documentation lists the following as required: A copy of the document(s) confirming the legal name of the applicant (must be confirmed by the organization's Office of Research). Could you confirm what type of document CSA will accept and what type of confirmation is required from the Research Office Services?
Answer 3: The documentation required by CSA aims to confirm the legal name of the organization (this is necessary for a formal agreement to be drafted). It is typically enclosed in the letters patent, other constitutive documents, or the university Act and it can be provided by the Office of Research of your University.
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Question 4: We are in the process of completing an application for your AO and we have questions regarding the "Duly Authorized Representative "Signature: Is the" Duly Authorized Representative" the same person as the "Representative from the Office of Research"? Is the Chair of my research department sufficient to be this representative?
Answer 4:
- "The Duly Authorized Representative" can be the same person as the "Representative from the Office of Research", but it can also be another authorized representative of the University.
- The Chair of the research department cannot be this representative, the application has to be sign by the "Representative from the Office of Research" or a "duly authorized representative" of the University.
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Question 5: Regarding the application form, item 8 of Section 9 (Submission Checklist), it is written: "The applicant will ensure that ethical certification requirements are met. A letter signed by the chairperson of the local Institutional Review Board (IRB) regarding approval of the experimental protocol using human subjects will be required." Does the applicant need to have ethics approved and attach the ethical certificate to the application at the time of submission of the proposal or can the researcher submit the ethical certificate only prior to funding being released?
Answer 5: We require the researcher to submit ethical certificate to the Canadian Space Agency only prior to funding being released once the proposals have been selected. No documents regarding ethics approval are required when submitting the proposal.
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Question 6: In section 3 of the application form, is it possible to add more than 6 members of the research team? If yes, how?
Answer 6: Section 3 of the application form includes members of the research team, such as principal investigators and co-investigators. If you have more than 5 co-researchers, it is possible to include them by adding them in the table of the application form (editable Word document).
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Question 7: As per the OA for this funding opportunity, we understand that overhead/administrative costs are not to exceed 20% of eligible costs for universities. Is this 20% applies to all eligible costs or if there are any specific costs that should be excluded from overhead calculations (e.g., graduate student stipends or other research personnel costs)?
Answer 7: The 20% is applicable for all of eligible costs.
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Question 8: Would a PhD student be able to apply to the AO along with their supervisor (a professor) who would be the PI on the project?
Answer 8: As indicated in the Announcement of Opportunity (AO), the principal investigator (PI) or Co-Investigator (Co-I) listed must be a Canadian Researcher and must hold a traditionally recognized academic position such as professor, associate professor, assistant professor, or professor emeritus (post-doctoral fellows cannot be considered as PI or Co-I). However, the participation of students in projects submitted to this AO is encouraged and stipends for students involved in the project are eligible costs as per the AO (section 6.2).
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Question 9: Can you confirm that only proposals that are selected by international space agencies Announcement of Opportunities (AOs) are eligible for the CSA Human Analogue Studies AO?
Answer 9: This is correct. As indicated in the Human Analogue Studies Announcement of Opportunity in the section '3.2 - Eligible Projects', the proposals eligible for funding in this solicitation process are those proposals that have been selected based on scientific merit through one of the international partner competitions. However, CSA offers other AOs such as the Flights and Fieldwork for the Advancement of Science and Technology (FAST) AO, where funding can be provided for projects that use simulated/analogue space environments to better understand health on Earth or to develop better ways to monitor or maintain health on Earth, or to prevent or to treat diseases relevant to the Canadian population, or to advance health systems research.
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Question 10: Can you confirm if research projects involving private astronaut missions are eligible for the Human Analogue Studies Announcement of opportunity (AO)?
Answer 10: Unfortunately, research projects involving private astronaut missions are not eligible for the Human Analogue Studies Announcement of opportunity (AO).
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Question 11: Are co-I in European Space Agency (ESA) projects, only eligible to a maximum grant of $150,000?
Answer 11: Yes, proposals submitted by Co-I are eligible to a maximum grant of $150,000 for a maximum duration of three (3) years.
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Question 12: Is the ethical approval of the experimental protocol using human subjects required with the initial submission of the proposal or, can it be sent later after proposal approval?
Answer 12: The letter of approval can be sent after the initial submission of the proposal once the project is selected. Although the ethical certification is mentioned in section 4 (Applications), if the ethics approval letter is not available at the time of submission, it can be provided once the project is funded.
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Question 13: Could you provide more information on project eligibility requirement? Are projects only eligible to this Human Analogue Study Announcement of Opportunity if they have been previously selected in international partners' competitions?
Answer 13: As indicated in the Human Analogue Studies Announcement of Opportunity in the section '3.2 - Eligible Projects', the proposals eligible for funding in this solicitation process are those proposals that have been selected based on scientific merit through one of the international partner competitions.
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Question 14: If a research team is selected by ESA for VIVALDI III, is it possible to apply to a CSA funding competition as a Co-Investigator?
Answer 14: Research teams that were selected by ESA to participate in VIVALDI III are eligible to apply for funding to the Human Analogue Studies Announcement of Opportunity. However, according to section 3.2 - Eligible Projects (the proposals eligible for funding in this solicitation process are those proposals that have been selected based on scientific merit through one of the international partner competitions), the applicants must provide proof that their research proposal has been selected by ESA for VIVALDI III specifically.
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Question 15: The submission checklist found in section 4.1 Required Documentation, indicate that the application must include the following: 'Letter of acknowledgement received from the partner agency showing that the project has been selected through one of the competitions. Applicants are also required to provide CSA with the results of the Science Merit Review when they are received. CSA will use this result as science merit score. Applicants must obtain a passing score from the international partner competition to be considered by CSA''. If an applicant applied to another Canadian competition and got selected, could they be eligible for this announcement of opportunity (AO)?
Answer 15: As indicated in the Human Analogue Studies Announcement of Opportunity in the section '3.2 - Eligible Projects', the proposals eligible for funding in this solicitation process are those proposals that have been selected based on scientific merit through one of the international partner competitions. International partner refers to other space agencies such as NASA, ESA, or JAXA. Unfortunately, the Canadian competitions are not eligible for this AO.
However, CSA offers other AOs such as the Flights and Fieldwork for the Advancement of Science and Technology (FAST) AO, where funding can be provided for projects that use simulated/analogue space environments to better understand health on Earth or to develop better ways to monitor or maintain health on Earth, or to prevent or to treat diseases relevant to the Canadian population, or to advance health systems research.
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Question 16: In section 12 - Legal Considerations of the application form, it is indicated in section A : "Does the Applicant have any claims/debts owed to any federal, provincial, municipal or territorial government or has it received an overdue claim from such an organization?". Could you clarify if this request is only concerning "claims/debts" subject to an overdue claim notice as opposed to claims or debts owed in the ordinary course of business?
Answer 16: This section only refers to "claims/debts" subject to an overdue claim notice.
CYCLE 1 RECIPIENTS
*Note – Cycle 1 includes both human analogue and DM and RM projects, subsequent cycles split these projects into two separate announcements of opportunity.
| Type | Organization | Project title | Description | Total amount |
|---|---|---|---|---|
Data Mining |
University of Waterloo – Richard Hughson |
Extracting novel information from Canadian space life science astronaut data |
The current project will provide an opportunity for young, highly talented Canadian scientists to engage in data mining exercise that will leverage data collected from the CSA-supported projects BP Reg and Vascular. Novel hypotheses developed since these original studies can utilize spaceflight data to provide insights into blood pressure regulation and the effects of stiffer arteries on blood flow to the brain. Our results set the stage for applications of the CSA Bio-Monitor and advanced ultrasound technology to benefit astronauts in future long-duration exploration missions; and, they open opportunities to benefit health in the aging population on Earth. |
$ 70,000 |
Data Mining |
University of Montreal – Frédéric Pitre |
Impacts of long-term space travel upon astronaut health: analysis of MARS500 crew microbiomes using improved Metagenomics |
The microbiome is intricately involved in human health. One concern in spaceflight is the potential negative impact of long-term habitat confinement upon microbiome health. The MARS500 project investigated this by sampling the microbiome of six astronauts over the longest ground-based confined habitat experiment conducted to-date. The project objective is to determine common microbiome changes in the crew of the MARS500 experiment. Improved metagenomic assessment technologies mean that significant differences in microbiome species can be identified over the 520-day experiment. Findings should reveal insight into the long-term impacts of spaceflight upon astronaut health and provide a unique view of confined environments. |
$ 69,999 |
Research Models |
Unity Health Toronto – Yeni Yucel |
Disturb Fluid drainage Around Eye: An important Missing Piece in the Puzzle of Vision Loss in Astronauts? |
Vision loss due to Space Associated Neuro-Ocular Syndrome (SANS) is observed in many astronauts, is poorly understood and remains one of the most feared hazards of space flight. The loss of gravity causes fluid shifts and these disturbances around the eye may be an important piece of the puzzle. Novel non-invasive techniques will be used to examine eye and lymphatic fluid changes for the first time in a model of SANS. Discovering impaired entry and exit of fluid in and from around the eye will be an important step toward understanding and preventing vision loss from SANS in astronauts. |
$ 149,944 |
Research Models |
McGill University – Svetlana Komarova |
Understanding relative contributions of fluid flow and mechanical strain to bone adaptation in altered gravity. |
Bone loss in astronauts is a major challenge for long-duration space exploration. In weightlessness, muscles are used less often, thus providing less stimulation of bone. Microgravity also induces fluid shift from the lower body towards the head, the role of which in bone loss is unclear. We aim to develop imaging, computational and pharmacological tools to examine contributions of fluid flow and mechanical strain to bone adaptation to mechanical environment using mouse models of mechanical loading and immobilization-induced unloading. Understanding the links between microgravity and bone adaptation will help to prevent bone loss in long-duration human space flights. |
$ 150,000 |
Research Models |
Mount Saint Vincent University – Tamara Franz-Odendaal |
Understanding microgravity-induced bone loss through in vivo simulated microgravity experiments |
Following a space mission, astronauts experience severe bone thinning and increased risks of fracture when back on Earth. This anomaly is due to microgravity exposure. The aim of this study is to reproduce and expose fish larvae to a simulated microgravity on Earth, and to analyze the effects on the cells of the skeleton. Fish bones strongly resemble human bones in structure. They utilize similar cell types to secrete, mineralize and degrade bone matrix, and similar signaling pathways for cell-cell communication. Thus, fish are a good model to understand the causes underlying the microgravity-induced bone fragility observed in astronauts |
$ 150,000 |
Research Models |
University of Ottawa – Odette Laneuville |
An animal model to prevent shoulder injuries in microgravity |
Shoulder's muscles and tendons combine their activities to provide mobility and stability when we move our arms. On Earth, shoulder muscles must counteract gravity to maintain in position the shoulder. In space, only muscle forces act and astronauts develop shoulder overuse injuries. Our ability to detect early signs of shoulder overuse is limited. As such, soft tissue tears develop unnoticed until they cause pain and serious functional deficits. We propose to study the shoulders of mudskippers, an amphibious fish, as a natural model that mirrors the dramatic changes in motions, gravitational forces experienced by astronauts' shoulders |
$ 15,000 |
Human Analogues |
Simon Fraser University – Andrew Blaber |
Effect of individualized Artificial Gravity Training on Cardiovascular and Cerebral Responses in Males and Females during Supine to Stand tests |
Wobbly legs, dizzy spells and even fainting experienced by astronauts on return to Earth are serious health and safety concerns. One solution may be to provide artificial gravity from a centrifuge in space. Our group has shown that artificial gravity training on Earth increases standing tolerance, but the reasons behind this increase are not well understood, particularly for women who have not been included as often in previous studies. We will look the posture, cardiovascular and brain blood flow responses to an individualized artificial gravity program in men and women to better understand and use this technique to protect astronauts. |
$ 99,340 |
Human Analogues |
York University – Laurence Harris |
CSA Smug: Self-motion under gravity |
When humans move from the normal constant one gravity environment found on earth a range of different perceptual systems must operate under unusual conditions resulting the systematic errors in fundamental measures including the perception of self-motion. Understanding how humans integrate cues to their self-motion under such circumstances is critical for humans to operate safely and effectively off earth. In collaboration with German partners and the DLR, the CSASMUG project is building a model of how humans integrate gravity and other cues to estimate their self-motion and is developing countermeasures and display technology based on this model. |
$ 147,840 |
CYCLE 2 RECIPIENTS
| Organization | Project title | Description | Total amount |
|---|---|---|---|
University of Waterloo – Richard Hughson |
Effects of bed rest artificial gravity and exercise on total hemoglobin and blood volume relation to orthostatic tolerance and aerobic capacity |
Human spaceflight or prolonged periods of bed rest on Earth causes deconditioning of the cardiovascular system that can result in loss of physical fitness and impaired regulation of blood pressure on return to upright posture. Development of countermeasures to overcome these effects is a major goal of the Canadian Space Agency. In this study of 60-days head down bed rest, artificial gravity generated on a large centrifuge, and exercise training will be introduced to determine their effectiveness. Changes in blood volume and regulatory hormones will be followed to assess their contribution to loss of cardiovascular fitness. |
$ 100,000 |
University of Waterloo – Richard Hughson |
ArtificiaL gravity mitigates bedrest bOne and cArDiovaScular deconditioning LOADS |
This project provides a rare opportunity to investigate simultaneous changes within the heart, blood vessels and skeleton in both men and women that volunteer to spend 60-days in bed, mimicking the reduced physical demands required of humans during spaceflight. We will test novel hypotheses that aim to identify potential links between the blood vessels and the bones of the skeleton, thereby identifying new and important avenues for future spaceflight and health-related research. Additionally, we will evaluate any beneficial effects of physical exercise and artificial gravity during bedrest that may limit the deleterious consequences of inactivity on the human body. |
$ 69,999 |
Ottawa Hospital Research Institute – Guy Trudel |
Effectiveness of artificial gravity (AG) and its combination with bike ergometer exercise on several musculoskeletal endpoints compared to controls and previous AG and non – AG countermeasures |
Deterioration of muscle and bone is an important problem occurring in bedrest and space flight. Resistance exercise using high mechanical loads showed promising results to mitigate bone loss. Artificial gravity alone was not sufficient to counteract the loss of bone strength. We hypothesized that AG in combination with resistive exercise will mitigate bone loss. We will use medical imaging and physiological measures of muscle and bone. Returning to full weight-bearing activities after bedrest and space flight with weakened muscles and reduced bone strength increases the risk of injury. Findings will lead to a deeper understanding of microgravity-induced musculoskeletal changes. |
$ 100,000 |
Ottawa Hospital Research Institute – Guy Trudel |
Effects of AG plus physical countermeasures in hypoxic environment on the hemolysis and anemia of long-term bedrest as a space analogue |
The SPIN Study will deliver novel and pertinent data on anemia, hemolysis, young, mature and senescent red blood cell populations and spleen changes in 24 participants before, during and after head-down tilt bed rest, with artificial gravity and physical countermeasures in hypoxia. The novel design, methods and data will allow testing unique hypotheses on the effects of artificial gravity and physical countermeasure and inspiratory fraction of oxygen on anemia, hemolysis mechanisms (neocytolysis and accelerated senescence), site of enhanced hemolysis (intravascular or extravascular) and organ involved (spleen, bone marrow) all crucial for future missions to the Moon or Mars. |
$ 200,000 |
Ottawa Hospital Research Institute – Guy Trudel |
Effectiveness of artificial gravity (AG) and its combination with resistive vibration exercise on several musculoskeletal endpoints compared to controls and previous AG and nonAG countermeasures |
Deterioration of muscle and bone is an important problem occurring in bedrest and space flight. Resistance exercise using high mechanical loads showed promising results to mitigate bone loss. Artificial gravity alone was not sufficient to counteract the loss of bone strength. We hypothesized that AG in combination with resistive exercise will mitigate bone loss. We will use medical imaging and physiological measures of muscle and bone. Returning to full weight-bearing activities after bedrest and space flight with weakened muscles and reduced bone strength increases the risk of injury. Findings will lead to a deeper understanding of microgravity-induced musculoskeletal changes. |
$ 100,000 |
Ontario Tech University – Carolyn McGregor |
Autonomous health monitoring for adaption assessment utilizing big data analytics during five-day dry immersion in an all-female crew |
Space Missions cause physiological changes in astronauts as they adapt to being in space. To date, a vast amount of knowledge has been gained on the impact of space missions on the physiology of biological males. As a result, the impact on biological females is less known. The ESA has proposed an Earth based simulation study involving a group of all female participants being immersed in dry immersion tanks to simulate weightlessness in space. This project proposes an innovative computing approach to analyse the adaption process from that ESA study. |
$ 50,000 |
Simon Fraser University – Andrew Blaber |
The pathophysiology risk, and clinical presentation of Venous Thromboembolisms (VTE) during headdown tilt bed rest: effects of supplemental daily centrifugal artificial gravity with or without exercise in normoxia or hypoxia in relation to body morphology factors. |
Recently an astronaut was found with Jugular vein thrombosis. Thrombosis is a blood clot in a blood vessel which could partly or entirely block blood flow. The blood clot could also break free and block blood flow in another vessel. This is of serious concern since blockage in the brain could cause a stroke or in the heart, a heart attack. This study will examine the physiology of blood clotting with volunteers in a 60-day bedrest study to simulate the weightlessness of spaceflight. This information will help us better understand venous clotting in astronauts and patients confined to bed. |
$ 24,360 |
CYCLE 3 RECIPIENTS
| Organization | Project title | Description | Total amount |
|---|---|---|---|
Simon Fraser University – Andrew Blaber |
Effects of Prolonged Exposure to a Space Analog Environment on Cardiovascular variability and Cardio-postural Interactions |
Wobbly legs, dizzy spells and even fainting experienced by astronauts on return to Earth are serious health and safety concerns. While a major part of this is the loss of the effect of gravity on the body, another may be related to being isolated in a small group. This results in stress which could result in reduced quality of life and health. This is not unlike what many of us experienced during the pandemic lock down. The HERA facility allows us to study how posture and cardiovascular function are affected in isolation to better protect astronauts and isolated older persons. |
$ 99,000 |
University of Guelph – Leah Bent |
Cutaneous sensitivity of the Human Foot Sole following 60 day Head Down Bed Rest with Countermeasures |
Decreased foot sole skin input significantly reduces lower limb muscle activity, affecting balance and navigation in our environment. The research team has shown that short duration space flight alters the sensitivity of these foot sole skin receptors. These changes were significantly correlated to deficits in balance control. The current Head Down Bed Rest model isolates the impact of body unloading as a mechanism for these sensory changes. The research team aims to understand how the unloading triggers changes in skin feedback and whether countermeasures will reduce or eliminate these changes. This work will have a major impact on astronaut health and mobility and has significant implications for healthy aging on Earth. |
$ 199,536 |
CYCLE 4 RECIPIENTS
| Organization | Project title | Description | Total amount |
|---|---|---|---|
University of Waterloo – Richard Hughson |
Analysis (VULCAN) Project: Application of a novel ultrasound imaging tool to characterize complex blood flow and venous thrombosis risk in reduced gravity |
The recent observation of a blood clot forming in the neck vein of an astronaut on the ISS could have been related to low or stagnant blood flow in the vein as astronauts no longer have a head-to-heart gravitational gradient during spaceflight. The current study will use novel high-frame rate ultrasound investigations of blood flow in the neck vein during parabolic flights that replicate the microgravity conditions of spaceflight. From the ultrasound signals, we will use vector flow imaging to assess across the full width of the vessel the potential for areas of stagnant flow that could elevate the risk for blood clot formation. These results could lead to an inflight diagnostic screening test and a tool for evaluation of potential countermeasures to prevent this serious health risk for astronauts. |
$ 297,656 |
University of British Columbia – Matthew Turnock |
Behaviour of spinal anesthesia in low-gravity environments |
Recent findings suggest that the VTE may occur during spaceflight. Jugular vesin thrombosis is rarely reported on Earth, but is associated with relatively poor outcomes. Therefore, there is a need to evaluate the upper body venous system, and the effects of microgravity on venous blood flow, blood viscosity, vessel distension, and inflammation. It is also necessary to provide a better description of the molecular mechanisms by assessing how blood clotting genes are differentially expressed under microgravity. To this end, the proposed research will 1) identify jugular vein status and coagulation changes in spaceflight analogue of dry immersion and bed rest by analysis of blood samples, and 2) investigate the molecular mechanisms that underlie the risk of VTEs by assessing the genes associated with coagulation. The ourcome of this project would be a better understanding of the potential underlying mechanisms of VTEs in spaceflight. |
$ 204,000 |
University of Montreal – Guido Simonelli |
Antarctica and the hibernating brain; The interaction between mental fatigue, hypoxia, exercise and sleep in an isolated, confined and extreme (ICE) environment [BREEZE] |
Extended exposure to the isolated and extreme conditions at the Concordia station may induce mental fatigue, a state associated with mood disturbances, safety concerns, and work errors. The BREEZE-project aims to comprehensively evaluate mental fatigue, sleep, and physical fitness during an Antarctic overwintering campaign by tracking psychological, (neuro)physiological, and behavioral parameters. Assessments will include questionnaires on fatigue, sleepiness, coping strategies, and mood, as well as polysomnography, exercise heart rate, genotype analysis, arterial oxygen saturation, actigraphy, and activity diaries. The study will focus on interindividual differences and their stability over time. Additionally, two countermeasures will be tested: acetazolamide supplementation to improve sleep quality and reduce mental fatigue, and oxygen-enriched physical exercise to enhance performance and consequently mitigate fatigue. Ultimately, the project aims to map mental fatigability changes and elucidate genotype-related variability in response to extreme environments. This multidisciplinary approach will advance understanding of fatigue mechanisms and inform development of effective interventions. |
$ 150,000 |
Simon Fraser University – Andrew Blaber |
The pathophysiology risk and clinical presentation of VTE during dry immersion and bed rest |
Recent findings suggest that VTE may occur during spaceflight. Jugular vein thrombosis is rarely reported on Earth, but is associated with relatively poor outcomes. Therefore, there is a need to evaluate the upper body venous system, and the effects of microgravity on venous blood flow, blood viscosity, vessel distension and inflammation. It is also necessary to provide a better description of the molecular mechanisms by assessing how blood clotting genes are differentially expressed under microgravity. To this end, the proposed research will 1) identify jugular vein status and coagulation changes in spaceflight analogue of dry immersion and bed rest by analysis of blood samples, and 2) investigate the molecular mechanisms that underlie the risk of VTEs by assessing the genes associated with coagulation. The outcome of this project would be a better understanding of the potential underlying mechanisms of VTEs in spaceflight. |
$ 149,568.70 |
ANNEX 1
| Criteria | Description | Scoring |
|---|---|---|
Eligibility of the applicant |
This criterion evaluates whether the application has been submitted from an eligible recipient as defined in Section 3.1. |
Pass Fail |
Eligibility of the project |
This criterion evaluates whether the application is an eligible project for this AO as defined in Section 3.2. |
Pass Fail |
Alignment with CSA priorities |
This criterion evaluates how the project will contribute to the CSA priorities as defined in Section 3.3. |
Pass Fail |
Alignment with G&C Program priorities |
This criterion evaluates how the project will contribute to the G&C Program objectives, as defined in Section 3.4. |
Pass Fail |
Meets program funding provisions in Section 6.1 |
This criterion evaluates whether the proposal meets program funding provisions described in Section 6.1 |
Pass Fail |
ANNEX 2
In this sectionappendix 2
Description of Evaluation Criteria
1. Benefits to Canada
1.1 Alignment with the priorities of the CSA and its Space Health & Life Sciences Program
Description: This criterion evaluates whether the proposed research objectives are aligned with the priorities of the CSA and its Space Health & Life science program. Do the research objectives directly address health risks associated with human space flights (per Table 2)?
- Minimum score required = 10
- Poor:
The research objectives in the proposal do not address a risk of human space flight as listed in Table 2. (Score: 0)
- Below average:
One (1) research objective in the proposal addresses a risk of human space flight as described in Table 2, but overall, the proposal only indirectly addresses this risk, or does not clearly demonstrate how the risk is addressed. (Score: 5)
- Average:
One (1) research objective in the proposal addresses one (1) risk of human space flight as described in Table 2 and describes how the risk is addressed, but the description is superficial or incomplete. (Score: 10)
- Good:
Some of the research objectives in the proposal directly address one (1) or more risks of human space flight as described in Table 2 and the proposal clearly describes how the risk is addressed. (Score: 15)
- Excellent:
All research objectives in the proposal directly and clearly address one (1) or more risks of human space flight as described in Table 2. (Score: 20)
1.2 Link to future space studies
Description: This criterion evaluates whether the proposed research objectives are direct precursors of future Canadian research projects on the ISS or Lunar Gateway. Provide a detailed explanation of the investigation(s) that would logically follow from the proposed research, which would require the ISS or the Lunar Gateway.
- Explain clearly how the proposed research can lead to a future investigation on the ISS or the Gateway.
- The research proposal should describe how the project will lead to novel operational countermeasure strategies against the risk of human spaceflight. List potential countermeasures, which could include preventative measures, interventions, treatments, etc.
- Minimum score required = 7
- Poor:
The research objectives are not direct precursors of future Canadian research projects on the ISS or Lunar Gateway and do not encompass countermeasure strategies. (Score: 0)
- Below average:
The proposal does not clearly demonstrate how the research objectives will lead to a future space research project and potential countermeasure are not mentioned. (Score: 4)
- Average:
The proposal demonstrates how the research objectives will lead to a future space research project, but this is not well justified. Potential countermeasures are briefly mentioned. (Score: 7)
- Good:
The proposal explains in detail how the research objectives will lead to a future space research projects and the description is justified, and potential countermeasures are listed. (Score:11)
- Excellent:
The proposal clearly demonstrates how the research objectives will lead to a future space research project and this explanation is well justified and provides a step-by-step plan to implement a follow-up investigation in space. Potential countermeasures are listed and clearly explained. (Score: 15)
1.3 Benefits on Earth
Description: This criterion evaluates whether the proposal demonstrates that the proposed research may contribute to the advancement of our understanding of similar health issues or applications on Earth, or that could contribute to improving health care for Canadians. Provide a clear explanation of how specifically this research can bring benefits on Earth (e.g.: which specific population, how it will benefit that population, etc.).
- Minimum score required = 10
- Poor:
The proposal does not address benefits on Earth, or the case for benefits is not clear or logical. (Score: 0)
- Below average:
The proposal indicates some benefits on Earth, but the justification for benefits is not well described and not fully clear. (Score: 5)
- Average:
The proposal indicates benefits on Earth, and the justification is included but it is general, or lacks precision. (Score: 10)
- Good:
One (1) or more of the research objectives has direct Earth benefits. A specific justification is provided and adequate. (Score: 15)
- Excellent:
Justification on how the proposed research will directly contribute to the advancement of our understanding of similar health issues or to improve health care for Canadians is clear, thorough, and persuasive. (Score: 20)
1.4 Equity, diversity, and inclusion (EDI)
Description: This criterion evaluates whether the research team has in the past fostered the recruitment and engagement of members of underrepresented groups within the research team, and if EDI measures are part of the current proposal plan. Underrepresented groups include, but are not limited to, the following four (4) designated groups: women, Indigenous peoples, members of visible minorities, and persons with disabilities. Applicants can consult the Employment equity website for definitions of each group. It also evaluates the different outreach activities proposed by investigators or the research team aiming the engagement and inclusion of underrepresented groups, inside or outside of the research laboratories or universities/institutions (e.g.: participation to committees and boards, conferences/colloquiums, workshops, and public dialogues).
- Note that journal club or lab meetings are not considered outreach activities with members of the underrepresented groups.
- Referencing the university policy is not considered a sufficient demonstration.
- Minimum score required = 1
- Poor:
The proposal does not describe any measure to promote the diversity within the team and does not mention any outreach activities. (Score: 0)
- Average:
The proposal describes means that were taken in the past or future actions that will be taken to engage members of the underrepresented groups or mentions one (1) outreach activity. (Score: 2)
- Excellent:
The proposal contains both means that were taken in the past as well as future actions that will be taken to recruit and engage members of underrepresented groups. The proposal also mentions at least one (1) outreach activity. (Score: 5)
2. Project Feasibility, Resources allocation, and Mitigation strategies
2.1 Budget, Resources Allocation and Schedule
Description: This criterion evaluates the adequacy of the budget, resource allocation to tasks (roles and responsibilities of students/HQPs) and material resources as well as project schedule. Applicants must present in their application an itemized budget that clearly describes project expenditures and sources of funding. Justification for the requested funds needs to be complete. The application must also show resource (human & funds) allocation to tasks for each individual involved in the project, as well as project schedule. Applicants are encouraged to seek co-funding and should clearly indicate co-funding in their budget.
- Minimum score required = 10
- Poor:
The proposal presents an incomplete or inadequate description of budget, resource allocation, and schedule, and/or inadequate justification of project expenditures. (Score: 0)
- Below average:
The budget, resource allocation (roles and responsibilities) and schedule are presented, however, information is missing, or the justification of expenditure is incomplete, or some expenditures are misevaluated or unrealistic/exaggerated. (Score: 5)
- Average:
The budget, resource allocation (roles and responsibilities) and schedule are presented, however, some information may be missing, or the justification of expenditure may sometimes be incomplete, or some expenditures are not defined well enough. (Score: 10)
- Good:
Appropriate budget and allocation of resources (roles and responsibilities) are presented. Schedule planning is feasible and realistic. Justification of project expenditures is appropriate, with no major omissions. (Score: 15)
- Excellent:
The budget, resource allocation and schedule (roles and responsibilities) are presented in a detailed and clear manner. Justification of resources is clear and comprehensive. The allocation of resources with clear and comprehensive justification are provided. (Score: 20)
2.2 Risk Management and Mitigation strategies
Description: This criterion evaluates the identification of potential pitfalls and obstacles that may occur during the project, as well as the adequacy of proposed preventive/remedial measures. The proposal shall address key risks associated with the project and the mitigation strategies for each. Information should be provided on resource availability, risks associated with their non-availability and, the risk and mitigation strategies associated with those risks. The following points are particularly important:
- Has the applicant identified and described in detail the risks associated with the project, including, but not limited to, financial, technical (e.g.: execution of research protocols, Research Ethics Boards approval), and managerial risks (e.g.: human resource back-up plans in case of departure of a team member)?
- Are the resources available to the research team, or was an agreement made to ensure implementation of the project?
- Are the mitigation strategies for each risk correctly addressed and realistic?
- Minimum score required = 10
- Poor:
The proposal does not identify any key risks or mitigation strategies, or some risks may be identified but related mitigation strategies are missing. (Score: 0)
- Below average:
The proposal identified risks, but the related mitigation strategies proposed appear inadequate. (Score: 5)
- Average:
The proposal identified some, but not all, key risks and their mitigation strategies are defined. However, the information provided is not sufficient and some details are missing. (Score: 10)
- Good:
The proposal demonstrates general understanding of key risks and potential pitfalls for this type of project and proposes elements of preventive/remedial measures to ensure feasibility of the study and their justification is well developed. (Score: 15)
- Excellent:
The proposal demonstrates clear understanding of key risks and obstacles/pitfalls accompanied by a thorough and adequate discussion of preventive/remedial measures to ensure completion of the study with quality results. Key risks and their mitigation strategies are well described, and the risk assessment is realistic. (Score: 20)
3. Results
3.1 Results of Scientific Merit Review:
Description: For this criterion, the Scientific Merit Review score from international partners will be used as a measure of science merit (peer-review). Applicants must have obtained a passing score from the international partner selection process to be considered in the CSA evaluation process. If the score of the International Partner Scientific Merit Review is not provided, the passing score will be awarded.